« My Front End Ethos »

Write valid, semantic markup
HTML should only be used to describe the content, not how to present it. Keeping it semantic (and valid) goes a long way in making it accessible by as many people as possible and ranking well with the search engines.
Separation of powers
Keep the HTML, CSS, and JavaScript separated: you'll reduce redundancy, thus reduce page weight, and also increase compatibility.
Avoid others blocking you
If a third-party external resource fails to load, it can completely block your page render. Avoid giving users a white page by loading those resources at the end of the body, in an iframe, or asyncronously.
Performance matters, a lot
Amazon discovered that for every 100ms delay, it cost them 1% of sales. No stone should be left unturned when it comes to page speed performance.
CSS in head, JS at bottom
You want to delight the user with how quickly and elegantly your page loads, so make sure the browser grabs the CSS before it begins rendering the page and then loads the potentially blocking JavaScript dead last. Fast and clean.
Be kind, leave comments
Well formatted, clean, and commented code should be an expected common courtesy of any developer. Don't leave your co-workers hanging when they're debugging your mistake.
Mobile is our future
The days of the desktop are nearing an end as mobile device sales are outpacing the PC. Account for mobile users by checking against Mobile Safari, Android Webkit, S40, and Opera Mobile (at the least).
Feature (not Browser) Detect
Thanks to libraries like Modernizr, we don't need to separate blocks of code to accommodate the quirks of a dozen browsers. Leverage these libraries to efficiently make your site cross-browser compatible.
Don't repeat yourself
Keep your code simple and maintable by avoiding needless repetition.
Progressively enhance
Begin by writing accessible, basic content for all browsers and then progressively enhance its style and behavior for browsers that support features like border radius, text shadow, and the canvas element. All browsers weren't created equally, we don't need to support them equally.
Optimize your images
Squeeze every last byte out of your images with tools like pngcrush, ImageMagick, jpegtran, and gifsicle to deliver the smallest possible file size without sacrificing any visual quality.
Dump the WYSIWYG editor
Dreamweaver? Expression? Clicking buttons to generate markup is NOT coding!